Hydrogen sulfide as a gasotransmitter
نویسندگان
چکیده
منابع مشابه
Blood pressure control: hydrogen sulfide, a new gasotransmitter, takes stage.
Hydrogen sulfide (H2S) is the most recently characterized autocrine/paracrine messenger implicated in the control of vascular tone. A series of coherent observations now document that this gas is a strong vasorelaxant and a determinant of blood pressure in experimental models. Targeted deletion of the gene encoding cystathionine-lyase (CSE). CSE, a key enzyme for H2S biosynthesis, reduces serum...
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Hydrogen sulfide (H2S) is a well-known environmental chemical threat with an unpleasant smell of rotten eggs. Aside from the established toxic effects of high-dose H2S, research over the past decade revealed that cells endogenously produce small amounts of H2S with physiological functions. H2S has therefore been classified as a "gasotransmitter." A major challenge for cells and tissues is the m...
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Hydrogen sulfide exists widely in mammalian tissues and plays a vital role in physiological and pathophysiological processes. However, striking differences with orders of magnitude were observed for the detected hydrogen sulfide concentrations in biological matrices among different measurements in literature, which lead to the uncertainty for examination the biological relevance of hydrogen sul...
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Hydrogen sulfide is a novel mediator with the unique properties of a gasotransmitter and many and varied physiological effects. Included in these effects are a number of cardiovascular effects that are proving beneficial to vascular health. Specifically, H2S can elicit vasorelaxation, prevention of inflammation and leukocyte adhesion, anti-proliferative effects and anti-thrombotic effects. Addi...
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Hydrogen sulfide (H2S) is recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy. It is produced by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). The activity of CBS is en...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2010
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2010.06580.x